从表观遗传学角度看母代运动对子代的健康效应

doi:10.15942/j.jcsu.2022.01.002

成都体育学院学报 ›› 2022, Vol. 48 ›› Issue (1): 8-13.doi: 10.15942/j.jcsu.2022.01.002

从表观遗传学角度看母代运动对子代的健康效应

石海旺, 段锐

华南师范大学体育科学学院, 广东广州 510006

收稿日期:2021-11-10 修回日期:2021-12-20 出版日期:2022-01-15 发布日期:2022-01-30
通讯作者: 段锐,博士,教授,研究方向:运动健康促进的机制、再生医学。E-mail:duanrui@m.scun.edu.cn。
作者简介:石海旺,博士研究生,研究方向:母代运动的健康效应。E-mail:shihaiw1024@126.com。
基金资助:
国家自然科学基金面上项目“长期有氧运动促进衰老小鼠肌卫星细胞融合效率的机制”(31971096)。

The Beneficial Health Outcomes of Maternal Exercise in offspring: From an Epigenetic Point of View

SHI Haiwang, DUAN Rui

School of Physical Education and Sports Science, SouthChina Normal University, Guangzhou Guangdong 510006

Received:2021-11-10 Revised:2021-12-20 Online:2022-01-15 Published:2022-01-30

摘要/Abstract

摘要： 母亲产前不良的生活方式和环境会导致胎儿生长发育过程中的风险因素显著增加。多项研究表明,母亲定期的体力活动对后代健康具有长期的积极效应,包括降低后代发生增龄性疾病的风险。文章通过介绍表观遗传调控及其影响因素在胎儿生长发育中的作用,系统阐述了母代运动对提高子代认知水平、代谢功能以及运动倾向的遗传效应及其表观遗传学机制,旨在为深入研究母代运动的代际效应提供一定的理论指导与研究思路。

关键词: 母代运动, 遗传效应, 代谢, 代际效应, 表观遗传学, 健康, 体力活动

Abstract: Mom’s unhealthy life style and/or living environment before childbirth can lead to significant increased risksfor the development of the fetus, and growth of the child. Many studies showed that regular maternal exercise has long-term positive health benefits in offspring, including but not limited to reducing the incidence of age-related diseases. We summarized the recent publications regarding the "reprogramming" effects of maternal exercise on fetal development through epigenetic regulations and discussed its mechanisms. This review may provide a theoretical basis and research ideas for the in-depth studies of the intergenerational effects of maternal exercise.

Key words: maternal exercise, genetic effect, metabolism, generational effect, epigenetic regulations, health, physical activity

中图分类号:

G804

石海旺, 段锐. 从表观遗传学角度看母代运动对子代的健康效应[J]. 成都体育学院学报, 2022, 48(1): 8-13.

SHI Haiwang, DUAN Rui. The Beneficial Health Outcomes of Maternal Exercise in offspring: From an Epigenetic Point of View[J]. Journal of Chengdu Sport University, 2022, 48(1): 8-13.

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链接本文: https://cdtyxb.cdsu.edu.cn/CN/10.15942/j.jcsu.2022.01.002

https://cdtyxb.cdsu.edu.cn/CN/Y2022/V48/I1/8

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从表观遗传学角度看母代运动对子代的健康效应

The Beneficial Health Outcomes of Maternal Exercise in offspring: From an Epigenetic Point of View

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