女性METH成瘾者脑效应连接特征及12周有氧训练干预实证研究

doi:10.15942/j.jcsu.2022.06.015

Abstract

Abstract: Objective: To study the characteristics of effective connectivity (EC) in female methamphetamine (METH) addicts and the intervention effect of 12-week aerobic training on addiction thirst, mood, and brain EC in addicts. Methods: The subjects were randomly divided into control group (CON group), METH addict group (METH group) and METH addict exercise group (METH-Ex group). Functional near-infrared spectroscopy (fNIRS) was used to collect cerebral blood oxygen signals. Sleep, depression, anxiety and thirst in subjects were assessed respectively by PSQI, SDS, SAS and DSQ scales. Both the METH group and the CON group received resting and exercise tests, and the METH-Ex group received a 12-week aerobic kickboxing training intervention of moderate intensity, and resting cerebral oxygenation tests, and mood and craving assessments were performed at 1st, 6th and 12th week. The cerebral blood oxygen signal data were transformed by Bayesian inference, the EC was tested according to Shapiro-Wilk, and data were analyzed by repeated measures ANOVA using SPSS 20.0. Results: There was a significant interaction between METH addiction and aerobic kickboxing exercise intervention on brain EC between LPFC-LMC, RPFC-LMC. The intensity of brain EC coupling in the resting METH group was significantly lower in LPFC-RPFC and LPFC-RMC than in the CON group; the intensity of brain EC coupling in the METH-Ex group was significantly lower in LPFC-RPFC, RPFC-LPFC, LPFC-LMC, LPFC-RMC, RPFC-LMC, RPFC-RMC, LMC-RMC than in the CON group, and RPE-Ex was negatively and significantly correlated with EC levels in LPFC-RPRC, RPFC-LPFC. Results of 12-week aerobic kickboxing exercise intervention in SDS, SAS, and DSQ groups were significantly different (P<0.01), and the level of depression, anxiety, and craving in subjects decreased significantly. The intensity of brain EC coupling in the METH-Ex group decreased significantly in LPFC-RPFC and RPFC-LPFC, while the intensity of brain EC coupling in LMC-RMC, LMC-LPFC, LPFC-RMC, RPFC-RMC, RMC-RPFC showed an increasing trend after the experiment. SDS had a significant moderate intensity correlation with the EC level of LMC-LPFC and LMC-RPFC, and SAS had a significant moderate intensity correlation with LPFC- RPFC, and DSQ showed a weak correlation with LPFC-RPFC and RPFC-LPFC. Conclusion: Brain EC in female METH addicts is lower than that in normal females, a single aerobic exercise intervention tends to reduce the EC level of METH addicts in exercise state, and RPE scale score is negatively correlated with EC change after the aerobic intervention; EC level in female METH addicts shows a decrease-increase trend after continuous aerobic kickboxing exercise intervention, indicating that long-term exercise intervention may have better effect on female METH addicts; aerobic kickboxing exercise intervention significantly lowers the level of depression, anxiety and METH craving in female METH addicts, and these changes are correlated with the EC between some cerebral regions.

Key words: aerobic exercise, female methamphetamine addicts, functional near-infrared spectroscopy, brain function network, effective connectivity

CLC Number:

G804.22

YU Jianhua, WU Yan, DU Jipeng, LU Xiaowen, LI Kefeng, YUAN Weijia, DONG Guijun. Characteristics of brain effective connectivity in female METH addicts and effect of 12-week aerobic training intervention[J]. Journal of Chengdu Sport University, 2022, 48(6): 93-100.

References

[1] UNITED NATIONS OFFICE ON DRUGS AND CRIME. Global overview of drug demand and supply: latest trends, cross-cutting Issues[R]. World Drug Report 2018,2018.
[2] MORAIS A P D,PITA I R, FONTES-RIBEIRO C A, et al. The neurobiological mechanisms of physical exercise in methamphetamine addiction [J]. CNS Neurosci Ther, 2018, 24(2):85-97.
[3] CHULATHIDA C,SUMMON C. Global patterns of methamphetamine use [J].Curr Opin Psychiatry, 2015, 28:269–274.
[4] SAW Y M, POUDEL K C, KHAM N P. Assessment of HIV testing among young methamphetamine users in Muse, Northern Shan State, Myanmar [J]. BMC Public Health, 2014, 14:735.
[5] ROTH M E, COSGROVE K P, CARROLL M E. Sex differences in the vulnerability to drug abuse: a review of preclinical studies [J]. Neurosci Biobehav Rev, 2004, 28(6):533-46.
[6] SUNG Y H,YURGELUN-TODD D A. Decreased frontal lobe phosphocreatine levels in methamphetamine users[J]. Drug Alcohol Depend, 2013, 129:102–109.
[7] VEARRIER D, GREENBERG M I, MILLER S N, et al. Methamphetamine: history, pathophysiology, adverse health effects, current trends, and hazards associated with the clandestine manufacture of methamphetamine [J]. Dis Mon, 2012, 58(2):38-89.
[8] KOOB G F. Addiction is a reward deficit and stress surfeit disorder [J]. Front Psychiatry,2013,4:72.
[9] COURTNEY K E,RAY L A. Methamphetamine:an update on epidemiology, pharmacology, clinical phenomenology, and treatment literature[J]. Drug Alcohol Depend, 2014, 143:11-21.
[10] LIU J F, TIAN J, LI J X. Modulating reconsolidation and extinction to regulate drug reward memory[J]. Eur J Neurosci, 2019, 50(3):2503-2512.
[11] LYNCH W J, PETERSON A B, SANCHEZ V, et al. Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis[J]. Neurosci Biobehav Rev, 2013, 37(8):1622-1644.
[12] MOONEY L J,COOPER C,LONDON E D. Exercise for methamphetamine dependence: rationale, design, and methodology [J]. Contemp Clin Trials, 2014, 37(1):139-147.
[13] AMERICAN PSYCHIATRIC ASSOCIATION. Diagnostic and statistical manual of mental disorders, 4th ed [M]. Washington, DC: American Psychiatric Association, 1994:122-125
[14] ZORICK T, NESTOR L, MIOTTO K. Withdrawal symptoms in abstinent methamphetamine-dependent subjects [J]. Addiction, 2010, 105(10):1809-1818.
[15] MCKETIN R, MCLAREN J, LUBMAN D I, et al. The prevalence of psychotic symptoms among methamphetamine users [J]. Addiction, 2006, 101(10): 1473-1478.
[16] KING G, ALICATA D, CLOAK C, et al. Neuropsychological deficits in adolescent methamphetamine abusers[J]. Psychopharmacology, 2010, 212(2):243-249.
[17] LYOO I K, YOON S, KIM T S, et al. Predisposition to and effects of methamphetamine use on the adolescent brain [J]. Mol Psychiatry, 2015, 20(12):1516-1524.
[18] GOLDSTEIN R Z, VOLKOW N D. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications[J]. Nat Rev Neurosci, 2011, 12(11):652-669.
[19] SCHWARTZ D L, MITCHELL A D, LAHNA D L, et al. Global and local morphometric differences in recently abstinent methamphetamine-dependent individuals [J]. Neuroimage,2010, 50(4):1392-1401.
[20] NAKAMA H, CHANG L, FEIN G, et al. Methamphetamine users show greater than normal age-related cortical gray matter loss[J]. Addiction, 2011, 106(8):1474-1483.
[21] ANDERSON V, JACOBS R, ANDERSON P J. Executive functions and the frontal lobes: a lifespan perspective [M]. Taylor & Francis Group, LLC., NY, USA,2010:497-498.
[22] GILBERT S J, BURGESS P W. Executive function[J]. Curr Biol,2008,18: R110-R114.
[23] 吕淑艳,钟宝亮,朱军红,等.美沙酮维持治疗门诊患者抑郁焦虑共存与情绪状态、睡眠质量和功能缺损的关系[J].中国药物依赖性杂志,2013,22(4):286-291.
[24] 王丹逢,刘恩益,蓝晓嫦,等.中文版苯丙胺渴求量表信效度检验[J].中国医药科学,2016,6(13):9-12.
[25] LYNCH W J, PIEHL K B. Aerobic exercise attenuates reinstatement of cocaine-seeking behavior and associated neuroadaptations in the prefrontal cortex[J]. Biol Psychiatry, 2010, 68(8): 774-777.
[26] ABRANTES A M,FARRIS S G. Acute effects of aerobic exercise on affect and smoking craving in the weeks before and after a cessation attempt[J]. Nicotine Tob Res, 2018, 20(5):575-582.
[27] VERGOTTE G,TORRE K,CHIRUMAMILLA V C. Dynamics of the human brain network revealed by time-frequency effective connectivity in fNIRS[J]. Biomed Opt Express,2017,8(11):5326-5341.
[28] FRISTON K J. Functional and effective connectivity: a review [J]. Brain Connect, 2011, 1(1):13-36.
[29] HOSHI Y, TSOU B H. Spatiotemporal characteristics of hemodynamic changes in the human lateral prefrontal cortex during working memory tasks[J].Neuroimage,2003,20(3):1493-1504.
[30] JANG S H. A review of diffusion tensor imaging studies in motor recovery mechanism in stroke patients [J].Neurorehabilitation, 2011, 28(4):345-352.
[31] ZHOU Y,ZHAO M. Sex differences in drug addiction and response to exercise intervention: From human to animal studies. Frontiers in Neuroendocrinology [J]. Front Neuroendocrinol, 2016, 40:24-41.
[32] OKADA N,TAKAHASHI K ,NISHIMURA Y. Characterizing prefrontal cortical activity during inhibition task in methamphetamine-associated psychosis versus schizophrenia: a multi-channel near-infrared spectroscopy study[J]. Addiction biology, 2016, 21(2):489-503.
[33] ZUNG W W K. The measurement of affects: depression and, anxiety [J]. Mod Probl Pharmacopsychiatry, 1974, 7:170-188.
[34] LAM F M,HUANG M Z,LIAO L R,et al. Physical exercise improves strength, balance, mobility, and endurance in people with cognitive impairment and dementia: a systematic review[J].Journal of Physiotherapy,2018,64(1):14-15.
[35] XIE H,ZHANG M,HUO C. Tai Chi Chuan exercise related change in brain function as assessed by functional near–infrared spectroscopy [J]. Scientific Reports,2019,9(1):13198.
[36] MANDYAM C D, KOOB G F. The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery [J]. Trends Neurosci, 2012,35(4):250-260.
[37] YAU S Y,GIL-MOHAPEL J. Physical exercise-induced adult neurogenesis: a good strategy to prevent cognitive decline in neurodegenerative diseases? [J] BioMed Research International, 2014, 2014:403120.

Characteristics of brain effective connectivity in female METH addicts and effect of 12-week aerobic training intervention

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 7

Recommended Articles

Metrics

Comments

[1]	LI En, YE Kui, SUN Junzhi, SU Quansheng. Effect of 8-Week Swimming Exercise on Autophagy in Rats with Insulin Resistance Induced by High-Fat Diet [J]. Journal of Chengdu Sport University, 2019, 45(4): 121-126.
[2]	HU Haixu,LV Yujun. Research Progress of Physical Activities/Exercise Affecting Cognitive Health [J]. Journal of Chengdu Sport University, 2018, 44(2): 97-103.
[3]	ZHU Bin¹, CHEN Xueling², ZHANG Yeting¹. Research on the Laws of Rat Renal Function Recovery after Different Cycles of Sugar Aerobic Swimming Training [J]. Journal of Chengdu Sport University, 2017, 43(3): 109-114.
[4]	JIANG Li,WANG Di,YIN Jin. Comparative Study on the Two Training Models of "Plateau-Sub plateau-Plain" and "Plateau-Plain" of Middle and Long Distance Runners Living in Plateau [J]. Journal of Chengdu Sport University, 2017, 43(2): 67-71.
[5]	LIN Xue-ling, et al. Effect of aerobic exercise of different periods on rats brain aging and expression of NCAM gene in frontal lobe [J]. 成都体育学院学报, 2014, 40(6): 62-67.
[6]	WANG Xiaoyan. Effects of Aerobic Exercise on Rats’ Plasma in the Process of Atherosclerosis [J]. 成都体育学院学报, 2014, 40(12): 91-94.
[7]	GONG Xiao-Ming,et all. Effects of Aerobics on Proliferative Capacity in Endothelial Progenitor Cellsfrom Bone Marrow of Old Male Rats [J]. 成都体育学院学报, 2014, 40(10): 60-63.