从表观遗传学角度看母代运动对子代的健康效应

doi:10.15942/j.jcsu.2022.01.002

Abstract

Abstract: Mom’s unhealthy life style and/or living environment before childbirth can lead to significant increased risksfor the development of the fetus, and growth of the child. Many studies showed that regular maternal exercise has long-term positive health benefits in offspring, including but not limited to reducing the incidence of age-related diseases. We summarized the recent publications regarding the "reprogramming" effects of maternal exercise on fetal development through epigenetic regulations and discussed its mechanisms. This review may provide a theoretical basis and research ideas for the in-depth studies of the intergenerational effects of maternal exercise.

Key words: maternal exercise, genetic effect, metabolism, generational effect, epigenetic regulations, health, physical activity

CLC Number:

G804

SHI Haiwang, DUAN Rui. The Beneficial Health Outcomes of Maternal Exercise in offspring: From an Epigenetic Point of View[J]. Journal of Chengdu Sport University, 2022, 48(1): 8-13.

References

[1] PEREZ M F, LEHNER B. Intergenerational and transgenerational epigenetic inheritance in animals [J]. Nat Cell Biol, 2019, 21(2): 143-151.
[2] SKINNER M K. What is an epigenetic transgenerational phenotype? f3 or f2 [J]. Reprod Toxicol, 2008, 25(1): 2-6.
[3] HEIJMANS B T, TOBI E W, STEIN A D, et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans [J]. Proc Natl Acad Sci U S A, 2008, 105(44): 17046-17049.
[4] SARKIES P. Molecular mechanisms of epigenetic inheritance: possible evolutionary implications [J]. Semin Cell Dev Biol, 2020, 97: 106-115.
[5] VEENENDAAL M V, PAINTER R C, DE ROOIJ S R, et al. Transgenerational effects of prenatal exposure to the 1944-45 dutch famine [J]. BJOG, 2013, 120(5): 548-553.
[6] FERNANDEZ-TWINN D S, HJORT L, NOVAKOVIC B, et al. Intrauterine programming of obesity and type 2 diabetes [J]. Diabetologia, 2019, 62(10): 1789-1801.
[7] XUE Y, CHEN Y, AYUB Q, et al. Deleterious- and disease-allele prevalence in healthy individuals: insights from current predictions, mutation databases, and population-scale resequencing [J]. Am J Hum Genet, 2012, 91(6): 1022-1032.
[8] WADDINGTON C H. The epigenotype. 1942 [J]. Int J Epidemiol, 2012, 41(1): 10-13.
[9] RAKYAN V K, BLEWITT M E, DRUKER R, et al. Metastable epialleles in mammals [J]. Trends Genet, 2002, 18(7): 348-351.
[10] MCGEE S L, HARGREAVES M. Epigenetics and exercise [J]. Trends Endocrinol Metab, 2019, 30(9): 636-645.
[11] LYKO F. The dnamethyltransferase family: a versatile toolkit for epigenetic regulation [J]. Nat Rev Genet, 2018, 19(2): 81-92.
[12] FYODOROV D V, ZHOU B R, SKOULTCHI A I, et al. Emerging roles of linker histones in regulating chromatin structure and function [J]. Nat Rev Mol Cell Biol, 2018, 19(3): 192-206.
[13] VU L D, GEVAERT K, DE SMET I. Protein language: post-translational modifications talking to each other [J]. Trends Plant Sci, 2018, 23(12): 1068-1080.
[14] DASKALAKI M G, TSATSANIS C, KAMPRANIS S C. Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses [J]. J Cell Physiol, 2018, 233(9): 6495-6507.
[15] XAVIER M J, ROMAN S D, AITKEN R J, et al. Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health [J]. Hum Reprod Update, 2019, 25(5): 518-540.
[16] NILSSON E, KLUKOVICH R, SADLER-RIGGLEMAN I, et al. Environmental toxicant induced epigenetic transgenerational inheritance of ovarian pathology and granulosa cell epigenome and transcriptome alterations: ancestral origins of polycystic ovarian syndrome and primary ovarian insufiency [J]. Epigenetics, 2018, 13(8): 875-895.
[17] RADFORD E J, ITO M, SHI H, et al. In utero effects. In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism [J]. Science, 2014, 345(6198): 1255903.
[18] OGDEN C L, CARROLL M D, FLEGAL K M. Prevalence of obesity in the united states [J]. JAMA, 2014, 312(2): 189-190.
[19] ZHOU Q, WANG Q, SHEN H, et al. Prevalence of diabetes and regional differences in chinese women planning pregnancy: anationwide population-based cross-sectional study [J]. Diabetes Care, 2017, 40(2): e16-e18.
[20] GAILLARD R. Maternal obesity during pregnancy and cardiovascular development and disease in the offspring [J]. Eur J Epidemiol, 2015, 30(11): 1141-1152.
[21] SALES V M, FERGUSON-SMITH A C, PATTI M E. Epigenetic mechanisms of transmission of metabolic disease across generations [J]. Cell Metab, 2017, 25(3): 559-571.
[22] OU X H, ZHU C C, SUN S C. Effects of obesity and diabetes on the epigenetic modification of mammalian gametes [J]. J Cell Physiol, 2019, 234(6): 7847-7855.
[23] FOWDEN A L, SFERRUZZI-PERRI A N, COAN P M, et al. Placental efficiency and adaptation: endocrine regulation [J]. J Physiol, 2009, 587(Pt 14): 3459-3472.
[24] FOWDEN A L, FORHEAD A J, COAN P M, et al. The placenta and intrauterine programming [J]. J Neuroendocrinol, 2008, 20(4): 439-450.
[25] SOO P S, HISCOCK J, BOTTING K J, et al. Maternal undernutrition reduces P-glycoprotein in guinea pig placenta and developing brain in late gestation [J]. Reprod Toxicol, 2012, 33(3): 374-381.
[26] SFERRUZZI-PERRI A N, CAMM E J. The programming power of the placenta [J]. Front Physiol, 2016, 7: 33.
[27] COSTA M A. The endocrine function of human placenta: an overview [J]. Reprod Biomed Online, 2016, 32(1): 14-43.
[28] STANFORD K I, TAKAHASHI H, SO K, et al. Maternal exercise improves glucose tolerance in female offspring [J]. Diabetes, 2017, 66(8): 2124-2136.
[29] SON J S, CHAE S A, WANG H, et al. Maternal inactivity programs skeletal muscle dysfunction in offspring mice by attenuating apelin signaling and mitochondrial biogenesis [J]. Cell Rep, 2020, 33(9): 108461.
[30] KUSUYAMA J, ALVES-WAGNER A B, CONLIN R H, et al. Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health [J]. Cell Metab, 2021, 33(5): 939-956.
[31] DAVENPORT M H, RUCHAT S M, POITRAS V J, et al. Prenatal exercise for the prevention of gestational diabetes mellitus and hypertensive disorders of pregnancy: a systematic review and meta-analysis [J]. Br J Sports Med, 2018, 52(21): 1367-1375.
[32] VAN POPPEL M N M, SIMMONS D, DEVLIEGER R, et al. A reduction in sedentary behaviour in obese women during pregnancy reduces neonatal adiposity: the dalirandomised controlled trial [J]. Diabetologia, 2019, 62(6): 915-925.
[33] SON J S, LIU X, TIAN Q, et al. Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth [J]. J Physiol, 2019, 597(13): 3333-3347.
[34] BOSTROM P, WU J, JEDRYCHOWSKI M P, et al. A pgc1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis [J]. Nature, 2012, 481(7382): 463-468.
[35] SON J S, ZHAO L, CHEN Y, et al. Maternal exercise via exerkine apelin enhances brown adipogenesis and prevents metabolic dysfunction in offspring mice [J]. Sci Adv, 2020, 6(16): eaaz0359.
[36] CASSILHAS R C, TUFIK S, DE MELLO M T. Physical exercise, neuroplasticity, spatial learning and memory [J]. Cell Mol Life Sci, 2016, 73(5): 975-983.
[37] BLOOR C M. Angiogenesis during exercise and training [J]. Angiogenesis, 2005, 8(3): 263-271.
[38] NISHIJIMA T, PIRIZ J, DUFLOT S, et al. Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS [J]. Neuron, 2010, 67(5): 834-846.
[39] ROBINSON A M, BUCCI D J. Maternal exercise and cognitive functions of the offspring [J]. Cogn Sci (Hauppauge), 2012, 7(2): 187-205.
[40] JUKIC A M, LAWLOR D A, JUHL M, et al. Physical activity during pregnancy and language development in the offspring [J]. Paediatr Perinat Epidemiol, 2013, 27(3): 283-293.
[41] MARCELINO T B, LONGONI A, KUDO K Y, et al. Evidences that maternal swimming exercise improves antioxidant defenses and induces mitochondrial biogenesis in the brain of young wistar rats [J]. Neuroscience, 2013, 246(1):28-39.
[42] YANAGITA S, AMEMIYA S, SUZUKI S, et al. Effects of spontaneous and forced running on activation of hypothalamic corticotropin-releasing hormone neurons in rats [J]. Life Sci, 2007, 80(4): 356-363.
[43] HUGHES D C, ELLEFSEN S, BAAR K. Adaptations to endurance and strength Training [J]. Cold Spring Harb Perspect Med, 2018, 8(6): a029769.
[44] FABRE O, INGERSLEV L R, GARDE C, et al. Exercise training alters the genomic response to acute exercise in human adipose tissue [J]. Epigenomics, 2018, 10(8): 1033-1050.
[45] FRIEDMAN J E. Developmental programming of obesity and diabetes in mouse, monkey, and man in 2018: where are we headed? [J]. Diabetes, 2018, 67(11): 2137-2151.
[46] YANG Q, LIANG X, SUN X, et al. Ampk/alpha-ketoglutarate axis dynamically mediates dnademethylation in the prdm16 promoter and brown adipogenesis [J]. Cell Metab, 2016, 24(4): 542-554.
[47] VINEL C, LUKJANENKO L, BATUT A, et al. The exerkine apelin reverses age-associated sarcopenia [J]. Nat Med, 2018, 24(9): 1360-1371.
[48] LIU M, ZHOU L, XU A, et al. A disulfide-bond aoxidoreductase-like protein (dsba-l) regulates adiponectin multimerization [J]. Proc Natl Acad Sci U S A, 2008, 105(47): 18302-18307.
[49] AYE I L, ROSARIO F J, POWELL T L, et al. Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth [J]. Proc Natl Acad Sci U S A, 2015, 112(41): 12858-12863.
[50] DREWLO S, JOHNSON E, KILBURN B A, et al. Irisin induces trophoblast differentiation via ampkactivation in the human placenta [J]. J Cell Physiol, 2020, 235(10): 7146-7158.

The Beneficial Health Outcomes of Maternal Exercise in offspring: From an Epigenetic Point of View

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