运动联合二甲双胍对2型糖尿病乳酸代谢的影响:叠加还是拮抗作用

doi:10.15942/j.jcsu.2024.05.011

成都体育学院学报 ›› 2024, Vol. 50 ›› Issue (5): 92-100.doi: 10.15942/j.jcsu.2024.05.011

运动联合二甲双胍对2型糖尿病乳酸代谢的影响:叠加还是拮抗作用

姚武¹, 赵彤², 张媛³, 赵杰修⁴, 程蜀琳^1,5,6

1.上海交通大学体育系,上海 200240;
2.科隆体育大学心血管和运动医学研究所,德国科隆 50933;
3.南京体育学院运动健康学院, 江苏南京 210014;
4.国家体育总局体育科学研究所,北京 100061;
5.上海交通大学运动转化医学中心, 上海 200240;
6.于韦斯屈莱大学体育与健康科学学院,芬兰于韦斯屈莱 40014

收稿日期:2024-03-10 修回日期:2024-07-11 出版日期:2024-09-15 发布日期:2024-10-11
通讯作者: 程蜀琳,讲席教授,博士,研究方向:慢性病运动干预;E-mail:shulin.cheng@jyu.fi。
作者简介:姚武,副教授,学士,研究方向:慢性病运动干预;E-mail:yaowu@sjtu.edu.cn。

Combined Effects of Exercise and Metformin on Lactate Metabolism in Type 2 Diabetes Patients: Additive or Antagonistic?

YAO Wu¹, ZHAO Tong², ZHANG Yuan³, ZHAO Jiexiu⁴, CHENG Shulin^1,5,6

1. Physical Education Department, Shanghai Jiao Tong University, Shanghai 200240, China;
2. Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne 50933, Germany;
3. School of Sports and Health, Nanjing Sport Institute, Nanjing Jiangsu 210014, China;
4. Exercise Biology Center, China Institute of Sport Science, Beijing 100061, China;
5. Exercise Translational Medicine Center, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China;
6. Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä 40014, Finland

Received:2024-03-10 Revised:2024-07-11 Online:2024-09-15 Published:2024-10-11

摘要/Abstract

摘要： 2型糖尿病常伴有乳酸代谢异常。运动与二甲双胍为2型糖尿病的一线治疗方式,被《中国2型糖尿病防治指南》推荐联合使用。单独使用时,运动与二甲双胍均会影响乳酸代谢;但是,二者联合使用对乳酸代谢的影响尚未明确。文章总结了乳酸代谢与2型糖尿病、运动及二甲双胍的关系及相关机制,探讨运动和二甲双胍联合使用对2型糖尿病患者乳酸代谢的影响;并提出运动类型、服药剂量、运动时间和服药时间等相关因素的搭配问题,为2型糖尿病患者运动处方制定提供更多的理论参考。

关键词: 二甲双胍, 乳酸, 2型糖尿病, 运动干预, 体医融合

Abstract: Type 2 diabetes patients are often accompanied by abnormal lactate metabolism. Exercise and metformin are the first-line treatment for type 2 diabetes and are recommended to be used in combination, according to the Chinese Guidelines for Type 2 Diabetes. When exercise and metformin are used separately, it has been shown to affect lactate metabolism, while the combined effects have not been clearly defined. Therefore, the current study summarized the relationships among lactate metabolism, exercise, and metformin, as well as their related mechanisms in type 2 diabetes. Particularly, the study discussed the issues related to the factors i.e., exercise type, metformin dose, and timing of metformin taking and exercise, when using combination treatments of exercise and metformin to maximize the benefit and eliminate the side effect for type 2 diabetes patients.

Key words: metformin, lactate, type 2 diabetes, exercise intervention, integration of sports and medicine

中图分类号:

G804.5

姚武, 赵彤, 张媛, 赵杰修, 程蜀琳. 运动联合二甲双胍对2型糖尿病乳酸代谢的影响:叠加还是拮抗作用[J]. 成都体育学院学报, 2024, 50(5): 92-100.

YAO Wu, ZHAO Tong, ZHANG Yuan, ZHAO Jiexiu, CHENG Shulin. Combined Effects of Exercise and Metformin on Lactate Metabolism in Type 2 Diabetes Patients: Additive or Antagonistic?[J]. Journal of Chengdu Sport University, 2024, 50(5): 92-100.

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链接本文: https://cdtyxb.cdsu.edu.cn/CN/10.15942/j.jcsu.2024.05.011

https://cdtyxb.cdsu.edu.cn/CN/Y2024/V50/I5/92

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运动联合二甲双胍对2型糖尿病乳酸代谢的影响:叠加还是拮抗作用

Combined Effects of Exercise and Metformin on Lactate Metabolism in Type 2 Diabetes Patients: Additive or Antagonistic?

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