Abstract: Objective: To investigate the toxicity of Zheng’s Sanqisan (Notoginseng powder) on rats by taking different doses of Zheng’s Sanqisan. Method: 48 SD rats were randomly assigned to four groups: control group, conventional-dose group, medium-dose group and high-dose group,12 rats each group. The experiment lasted for 3 weeks. After the experiment, the testing index was blood urea nitrogen (BUN) and creatinine (Cr) and kidneys of rats. Result: (1) Three weeks of taking the medicine, the rats’ appearance and behavior remained normal. There were no significant differences in the weight of rats among different groups. (2) The renal capsule of rats in each group was complete and there were no pathological changes among groups. (3) There were no significant changes in renal weights and coefficients of rats among groups. (4)There were no significant differences in blood urea nitrogen and creatinine among different dose groups and control group. Conclusion: No side effect of Zheng’s Sanqisan was found between different dose groups and no significant changes in renal tissue cells were witnessed, either. There was no significant toxic difference in renal cell toxicology, therefore, different doses of Zheng’s Sanqisan are suitable for clinical practice.

Key words: Zheng’s Sanqisan, renal cells, toxicology