肌肉运动疲劳的生物标志物研究进展

doi:10.15942/j.jcsu.2021.02.021

成都体育学院学报 ›› 2021, Vol. 47 ›› Issue (2): 128-135.doi: 10.15942/j.jcsu.2021.02.021

• 运动训练与运动人体科学 • 上一篇下一篇

肌肉运动疲劳的生物标志物研究进展

赵海涛¹, 曹庆雷¹, 刘鑫², 李小兰¹

1.北京科技大学体育部,北京 100083;
2.北京科技大学化学与生物工程学院,北京 100083

收稿日期:2020-04-16 修回日期:2020-09-08 出版日期:2021-03-15 发布日期:2021-03-26
作者简介:赵海涛,副教授,研究方向:运动疲劳与康复,体育教学与训练。E-mail:zhangkj8877@126.com。

Research Progress on Biomarkers of Muscle Exercise Fatigue

ZHAO Haitao¹, CAO Qinglei¹, LIU Xin², LI Xiaolan¹

1. Department of Physical Education, University of Science and Technology Beijing, Beijing 100083;
2. School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083

Received:2020-04-16 Revised:2020-09-08 Online:2021-03-15 Published:2021-03-26

摘要/Abstract

摘要： 肌肉疲劳是指在进行肌肉收缩活动期间产生的做功能力下降现象,在运动过程中很常见,也是限制运动员提高成绩的主要原因之一。肌肉疲劳产生生物标志物可以评估在运动期间肌肉的疲劳程度和运动对骨骼肌的影响。肌肉疲劳主要是由于能量物质耗尽,氧化应激增加,炎症反应激活等机制造成的。此外,还涉及了脱水、高氨血症、线粒体生物发生和遗传反应,文章通过梳理,把肌肉疲劳的生物标志物分为两类:一类是非侵入式的生物标志物,主要包括肌肉功率输出测量、电生理测量、心脏功能测量和摄氧量等;另一类是侵入式的生物标志物,主要包括ATP代谢、氧化应激和炎症等相关的生化指标。以期对以后运动疲劳的诊断和新的生物标志物的开发提供有价值的信息。

关键词: 肌肉运动, 肌肉疲劳, 生物标志物

Abstract: Muscle fatigue is a phenomenon which refers to the decline in the ability of muscles to do work during muscle contraction. It is very common in the process of sports activities, and is one of the main reasons for preventing athletes from improving their performance.Muscle fatigue produces biomarkers that assess muscle fatigue during exercise and the effects of exercise on skeletal muscles.Muscle fatigue is caused by the depletion of nutrients, increased oxidative stress, and activation of inflammatory responses.In addition, it also involves dehydration, high ammonia concentration, mitochondrial biology and genetic reaction, and these reactions can be used to monitor biomarkers of sport fatigue. Through carding, the biomarkers of muscle fatigue are divided into two types: the noninvasive ones mainly including power output measurement, electrophysiological measurement, heart measurement and oxygen uptake, and the invasive ones mainly including biochemical indicators related to ATP metabolism, oxidative stress and inflammation.This paper aims to elaborate the recent research progress of biomarkers of muscle exercise fatigue and provide valuable information for the future diagnosis of exercise fatigue and the development of new biomarkers.

Key words: muscle exercise, muscle fatigue, biomarkers

中图分类号:

G804.2

赵海涛, 曹庆雷, 刘鑫, 李小兰. 肌肉运动疲劳的生物标志物研究进展[J]. 成都体育学院学报, 2021, 47(2): 128-135.

ZHAO Haitao, CAO Qinglei, LIU Xin, LI Xiaolan. Research Progress on Biomarkers of Muscle Exercise Fatigue[J]. Journal of Chengdu Sport University, 2021, 47(2): 128-135.

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: https://cdtyxb.cdsu.edu.cn/CN/10.15942/j.jcsu.2021.02.021

https://cdtyxb.cdsu.edu.cn/CN/Y2021/V47/I2/128

参考文献

[1] CHEUNG S M, KEENAN K, SENN N, et al. Metabolic and structural skeletal muscle health in systemic lupus erythematosus related fatigue: a multi-modal magnetic resonance imaging study[J]. Arthritis Care & Research, 2019, 71(12):1640-1646.
[2] RAINOLDI A, GAZZONI M, MERLETTI R, et al. Mechanical and EMG responses of the vastuslateralis and changes in biochemical variables to isokinetic exercise in endurance and power athletes[J]. J Sports Sci, 2008, 26(3):321-331.
[3] FINSTERER J. Biomarkers of peripheral muscle fatigue during exercise[J]. BMC Musculoskeletal Dis. 2012,13(1):218.
[4] PALACIOS G, PEDRERO-CHAMIZO R, PALACIOS N, et al. Biomarkers of physical activity and exercise[J]. NutrHosp, 2015, 31(S3):237-244
[5] SKURVYDAS A, STRECKIS V, MICKEVICIENE D, et al. Effect of age on metabolic fatigue and on indirect symptoms of skeletal muscle damage after stretch-shortening exercise[J]. J Sports Med Phys Fitness, 2006, 46(3):431-441.
[6] STENHOLM S, MAGGIo M, LAURETANI F, et al. Anabolic and catabolic biomarkers as predictors of muscle strengthdecline: the InCHIANTI study [J]. Rejuvenation Res, 2010, 13(1):3-11.
[7] WALKER S, PELTONEN H, AVELA J, et al. Neuromuscular fatigue in young and older men using constant or variable resistance[J]. Eur J ApplPhysiol, 2013, 113(4):1069-1079.
[8] SCHUBACK K, ESSéN-GUSTAVSSON B, Persson SG: Incremental treadmill exercise until onset of fatigue and its relationship to metabolic response and locomotion pattern[J]. Equine Vet J Suppl 2010, 31(S30):337-341.
[9] SIEGEL A J, JANUZZI J, SLUSS P, et al. Cardiac biomarkers, electrolytes, and other analytes in collapsed marathon runners: implications for the evaluation of runners following competition[J]. Am J ClinPathol, 2008, 129(6):948-951.
[10] HALSON S L. Monitoring training load to understand fatigue in athletes[J]. Sports Med, 2014, 44(S2): S139-147.
[11] NAVALTA J W, HRNCIR S P. Core stabilization exercises enhance lactate clearance following high-intensity exercise[J]. J Strength Cond Res, 2007, 21(4):1305-1309.
[12] HARDIE D G. AMP-activated protein kinase: a key system mediating metabolic responses to exercise[J]. Med Sci Sports Exerc,2004, 36(1):28-34.
[13] CALVERT L D, SINGH S J, GREENHAFF P L, et al. The plasma ammonia response to cycle exercise in COPD[J]. EurRespir J,2008, 31(4):751-758.
[14] BIANCHI G P, GROSSI G, BARGOSSI A M. May peripheral and central fatigue be correlated? Can we monitor them by means of clinical laboratory tools[J].J Sports Med Phys Fitness, 1997,37(3):194-199.
[15] SPERANZA L, GRILLI A, PATRUNO A, et al. Plasmatic markers of muscular stress in isokinetic exercise[J]. J BiolRegulHomeost Agents, 2007,21(1-2):21-29.
[16] HAMMOUDA O, CHTOUROU H, CHAHED H, et al. High intensity exercise affects diurnal variation of some biological markers in trained subjects[J]. Int J Sports Med, 2012,33(11):886-891.
[17] JAMMES Y, STEINBERG J G, DELLIAUX S, et al. Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses[J]. J Intern Med, 2009, 266(2):196-206.
[18] WARD W F, QI W, VAN REMMEN H, et al. Effects of age and caloric restriction on lipid peroxidation: measurementof oxidative stress by F2-isoprostane levels[J]. J Gerontol A BiolSci Med Sci, 2005, 60(7):847-851.
[19] ANDERSON N L, ANDERSON N G: The human plasma proteome: history,character, and diagnostic prospects[J]. Mol Cell Proteomics,2002, 1:845-867.
[20] BLOOMER R J, GOLDFARB A H, WIDEMAN L, et al. Effects ofacute aerobic and unaerobic exercise on blood markers of oxidativestress[J]. J Strength Cond Res,2005, 19(2):276-285.
[21] KERASIOTI E, KISKINI A, VESKOUKIS A, et al. Effect of a special carbohydrate-protein cake on oxidative stress markers after exhaustive cycling in humans[J]. Food ChemToxicol, 2012, 50(8):2805-2810.
[22] PINHEIRO C H J,VITZEL K F,CURI R. Effect of N-acetylcysteine on markers of skeletal muscle injury after fatiguing contractile activity[J]. Scandinavian journal of medicine & science in sports,2012,22(1):24-33.
[23] PEPE H, BALCI S S, REVAN S, et al. Comparison of oxidative stress and antioxidant capacity before and after running exercises in both sexes[J]. Gend Med, 2009, 6:587-595.
[24] WOO J, LEUNG S S, LAM C W, et al. Plasma totalantioxidant capacity in an adult Hong Kong Chinese population[J]. ClinBiochem, 1997, 30(7):553.
[25] HAMMOUDA O, CHTOUROU H, CHAHED H, et al. Diurnal variations of plasma homocysteine, total antioxidant status, and biological markers of muscle injury during repeated sprint: effect on performance and muscle fatigue-a pilot study[J]. ChronobiolInt, 2011, 28(10):958-967.
[26] KANTER M M, NOLTE L A, HOLLOSZY J O. Effects of an antioxidant vitaminmixture on lipid peroxidation at rest and post exercise[J]. J ApplPhysiol,1993, 74(2):965-969.
[27] BRANDT C, PEDERSEN BENTE K.The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases[J].Journal of biomedicine & biotechnology,2010(1): 520258.
[28] CHATZINIKOLAOU A, FATOUROS I G, GOURGOULIS V, et al. Time course of changes in performance and inflammatory responses after acute plyometric exercise[J]. J Strength Cond Res, 2010, 24(5):1389-1398.
[29] ABIáN-VICEN J, SALINERO J J, GONZáLEZ-MILLáN C, et al. Running pace decrease during a marathon is positively related to blood markers of muscle damage[J]. PLoS One, 2013,8: e57602.
[30] GOETZL E J, HUANG M C, KON J, et al. Gender specificity of altered human immunecytokine profiles in aging[J].FASEB J,2010, 24(9):3580.
[31] STOUT J R, FRAGALA M S, HOFFMAN J R, et al. C-terminal agrin fragment is inversely related to neuromuscular fatigue in older men[J]. Muscle Nerve, 2015,51(1):132-133.
[32] BALSALOBRE-FERNáNDEZ C, TEJERO-GONZáLEZ C M, DEL CAMPO-VECINO J. Relationships between training load, salivary cortisol responses and performance during season training in middle and long-distance runners[J]. PLoS One, 2014,9(8): e106066.
[33] HAMMOUDA O, CHTOUROU H, CHAHED H, et al. Diurnal variations of plasma homocysteine, total antioxidant status, and biological markers of muscle injury during repeated sprint: effecton performance and muscle fatigue-a pilot study[J].ChronobiolInt, 2011,28(10):958-967.
[34] MANO T, KATSUNO M, BANNO H, et al. Tongue pressure as a novel biomarker of spinal and bulbar muscular atrophy[J]. Neurology, 2014,82(3):255-262.
[35] CHATZINIKOLAOU A, FATOUROS I G, GOURGOULIS V, et al. Time course of changes in performance and inflammatory responses after acute plyometric exercise[J]. J Strength Cond Res, 2010, 24(5):1389-1398.
[36] NAEEM J, HAMZAID N A, ISLAM M A, et al. Mechanomyography-based muscle fatigue detection during electrically elicited cycling in patients with spinal cord injury[J]. Medical & Biological Engineering & Computing, 2019,57:1199-1211.
[37] CIFREK M, MEDVED V, TONKOVIC S, et al. Surface EMG based muscle fatigue evaluation in biomechanics[J]. ClinBiomech (Bristol, Avon), 2009,24(4):327-340.
[38] GONZALEZ-IZAL M, LUSA CADORE E, IZQUIERDO M. Muscle conduction velocity, surface electromyography variables, and echo intensity during concentric and eccentric fatigue[J]. Muscle Nerve, 2014,49(3):389-397.
[39] KASHIGAR A, UDUPA K, FISH J, CHEN R. Neurophysiological assessment of fatigue in electrical injury patients[J]. Exp Brain Res, 2014,232(3):1013-1023.
[40] ZUNIGA J M, HOUSH T J, CAMIC C L, et al. A mechanomyographic fatigue threshold test for cycling[J].Int J Sports Med, 2010,31(09):636-643.
[41] CHEN S W, LIAW J W, CHANG Y J, et al. A cycling movement based system for real-time muscle fatigue and cardiac stress monitoring and analysis[J]. PLoS One, 2015,10(6): e0130798.
[42] SMITH-RYAN A E, WOESSNER M N, MELVIN M N, et al. The effects of beta-alanine supplementation on physical working capacity at heart rate threshold[J]. ClinPhysiolFunct Imaging, 2014, 34:397-404.
[43] DINGWELL J B, JOUBERT J E, DIEFENTHAELER F, et al. Changes in muscle activity and kinematics of highly trained cyclists during fatigue[J]. IEEE Trans Biomed Eng, 2008,55(11):2666-2674.
[44] CHEN S W, LIAW J W, CHAN H L, et al. A real-time fatigue monitoring and analysis system for lower extremity muscles with cycling movement[J].Sensors (Basel), 2014,14(7):12410-12424.
[45] 侯言旭, 姜礼杰, 胡保华, 等. 基于边际谱熵的肌肉疲劳实时评估方法研究[J]. 仪器仪表学报, 2017, 038(007):1625-1633.
[46] QIN J, LIN J H, FABER G S, et al. Upper extremity kinematic and kinetic adaptations during a fatiguing repetitive task[J]. J ElectromyogrKinesiol, 2014,24(3):404-411.
[47] RANNOU F, NYBO L, ANDERSEN J E, et al. Monitoring Muscle Fatigue Progression during Dynamic Exercise[J]. Medicine & science in Sports & Exercise, 2019,51:1498-1505.

肌肉运动疲劳的生物标志物研究进展

Research Progress on Biomarkers of Muscle Exercise Fatigue

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐

Metrics

本文评价