关键词: 亚铁螯合酶, 基因多态性, 左心室结构, 功能

Abstract: Objective: To investigate the association between the rs1787997 polymorphism of FECH gene and left ventricular structure and function, and explore the feasibility that SNP rs1787997 has as genetic mark for predicting the effect of aerobic endurance training in men of Han nationality in Northern China. Methods: 102 healthy young male soldiers of Han Nationality in Northern China were recruited to undergo 18-week 5000m running with the intensity of 95%-105% anaerobic threshold with 3 times a week. Left ventricular structure and function parameters under different loads were measured before and after protocol. The PCR-RFLP and gene sequencing was used to analyze the distribution of this polymorphism. The association of the polymorphism with initial endurance capacity and endurance training response was analyzed. Results:(1)Before 18-week 5000m running, the initial mean value of the inter ventricular septal wall thickness systolic(IVSS), left ventricular posterior wall systolic(PWS), cardiac cycle(T) under 100W load in CG genotype were significantly higher than in CC or GG genotype(P <0.05).(2)After 18-week 5000m running, the increased degree of cardiac cycle(T) under 150W load and recovery in CG genotype was significantly higher than in GG genotype (P <0.05). Conclusion: In the rs1787997 polymorphism of FECH Gene, CC genotype has not only initial genetic advantage, but also higher training response in cardiac structure and function to aerobic training, and it could be the genetic marker in predicting endurance training response.

Key words: ferrochelatase, gene polymorphism, aerobic performance, left ventricular structure, function