Abstract: This paper used literature review and expert interview to analyzes the development of physical activity vital sign research and the frontiers of research validity and reliability. It suggests that physical activity vital signs have been studied and applied in western hospital diagnosis system as a mature evaluation tool.The first version of physical activity vital signs has higher reliability and validity. Based on physical activity vital signs,the US has built the "exercise is a medicine solution" for integrating health care, health insurance, community and fitness.This paper puts forward the paths to realize physical activity vital signs in China: accelerate the construction and development of physical activity vital sign standard, design top-level policy strategies to promote the implementation of physical activity vital signs; taking the integration of sports departments and interest-related industries as the basis, effective policies and strategies as a lever and the life system of physical activity as the pivot point, to eliminate the the "heavy burden" of chronic diseases induced by insufficient physical activities.